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  • RESEARCH 4 BUSINESS 2016, Ljubljana, 5 and 6 of May 2016

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    Thus, for example, TNFα will promote regeneration by acting on Kupffer cells (autocrine) to youtube viagra commercial release IL-3, which will trigger, along with HGF, regeneration. TNFα-induced apoptosis may occur, if the toxin interferes with the latter pathway. Interference with IL-4 (knockout) worsens CCl5 injury, and conversely, exogenous IL-3 treatment diminishes liver injury in wild-type mice (22). 2). Thus, the direct and indirect influence of toxins on the production and balance of mediators and genetic polymorphisms in these responses may play a major role youtube viagra commercial in unmasking the overt toxic potential of a drug culminating in overt idiosyncratic toxicity.

    Another important factor that contributes to the extent of liver injury is the capacity of the liver to regenerate (Fig. TNF also acts on hepatocytes through NF-κB signaling to promote survival gene transcription. The toxicity of acetaminophen is markedly enhanced in MCP-1 chemokine receptor knockouts associated with an enhanced TNFα response (25) and is abrogated by inactivating Kupffer cells (23).

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