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  • RESEARCH 4 BUSINESS 2016, Ljubljana, 5 and 6 of May 2016

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    Rather, endocannabinoids are synthesized when required in response to depolarization by receptor-stimulated cleavage of membrane lipid precursors and released from cells immediately after their production (Piomelli womens viagra video et al., 1996), fulfilling more a role of a neuromodulator (Piomelli et al., 1996) (Fig. Both anandamide and 2-AG can be hydrolyzed (Fig, once inside cells. They are not synthesized in the cytosol of neurons or stored in synaptic vesicles to be secreted by exocytosis following excitation of nerve terminals by action potentials.

    6.31). Once released, endocannabinoids act on cannabinoid receptors or are taken back into cells via an energy-independent transport system (Beltramo et al., 1997). 7.31).

    The endocannabinoids do not fulfill all of the requirements of ‘classical’ neurotransmitters.

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