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    D4 and D4 knockout mice show hyperactivity but no blunting of psychostimulant activity, and in some cases supersensitivity to psychostimulants (Rubinstein et al., 1996). Maldonado et al., 1998). Preliminary results show that D2 knockout mice actually selfadminister more cocaine than their wildtype littermates, an effect similar to that observed from pharmacological blockade of D2 receptors in intact mice (Caine et al., 2000b). Giros et al., 1997).

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