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    The arcuate nucleus, the paraventricular nucleus, and the lateral where to buy legal viagra in uk hypothalamic area are thought to be particularly important in different aspects of this control. Leptin is produced by adipocytes in proportion to the amount of body fat. Insulin, leptin, and ghrelin Figures 14-14 and 12-16).

    Because the blood-brain barrier in the arcuate nucleus is weak compared to most other brain regions, circulating peptides have access to arcuate neurons. Neurons in the hypothalamus transduce circulating hormones that indicate the metabolic and nutritional state of the organism into a coordinated response that involves changes in cellular metabolism, gastrointestinal physiological changes, and behavior. Insulin, produced by the pancreas, circulates in relation to body energy balance (ie, the difference between energy consumed and energy expended).

    Arcuate neurons are sensitive to three circulating hormones that play important roles in the control of feeding. Both leptin and insulin are signals that act to inhibit food intake and increase energy expenditure.

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