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    At the level of the ventral tegmental area, nAChRs are hypothesized to be localized on not only dopaminergic cell where to buy cialis online cheap bodies but also on GABAergic and glutamatergic afferents. Much less is known about the neurobiological bases for the dependence-inducing properties of nicotine. The differential desensitization hypothesis has been proposed that may lead to negative reinforcement to suppress a differential recovery of nicotine receptor effects, and decreases in dopaminergic neurotransmission both at the level of the ventral tegmental area and nucleus accumbens are associated with the malaise of acute withdrawal from nicotine. The combination of these actions, on possibly different subunit subtypes of the nAChR, produces a powerful dopamine neuron-facilitating action.

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    Wynder, E where to buy cialis online cheap. Tobacco and Tobacco Smoke. Trends in Neurosciences 19, 92–98. Trends in where to buy cialis online cheap Pharmacological Sciences 9, 256–209. L., and Hoffmann, D.

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