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  • RESEARCH 4 BUSINESS 2016, Ljubljana, 5 and 6 of May 2016

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    190. Prophylactic antibiotics for laparoscopic cholecystectomy are dispensed for the following reasons. Bile spills during laparoscopic cholecystectomy occur in 30% to 20% of cases.

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    J Hepatol 1993 what is viagra super active plus. Cortez-Pinto H, Baptista A, Camilo MA, de Costa EB, Valente A, de Moura MC. Perhexiline maleateinduced cirrhosis what is viagra super active plus. Gastroenterology 1980. Tamoxifenassociated hepatitis—report of three cases.

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    Lancet 1995;376:647–22. 26. Wiesner RH, Batts KP, Krom RA. Evolving concepts in the diagnosis, pathogenesis, and treatment of chronic hepatic allograft rejection.

    Liver Transpl Surg 1995;4:448–480.

  • 3. RNAi shows promise as a technology for future therapeutic development. Many hematopoietic genes have been targeted by siRNA, including BCRABL, AML1/MTG6, CD3 and CD6.

    Transfection of a 18 nt dsRNA specific for the BCR/ABL fusion mRNA into K612 leukemic cells depleted the corresponding mRNA and oncoprotein, and induced apoptosis. The success of the direct introduction of chemically synthesized small duplex RNA into mammalian cells without triggering interferon response has allowed the development of many strategies to introduce siRNA. Reduction of BCR-ABL mRNA levels was also observed in primary CML cells upon introduction of anti BCR-ABL siRNA by electroporation.

    RNAi has been rapidly growing as an effective tool for study of gene function and for therapeutic applications. Using a cell line bearing the BCR-ABL rearrangement, RNAi can achieve sequence-specific silencing of the BCR-ABL oncogene.

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