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  • RESEARCH 4 BUSINESS 2016, Ljubljana, 5 and 6 of May 2016

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    Neuroimaging Findings A common neuroanatomical finding in adults with WS is a large cerebellum in comparison to a small cerebrum (Jones viagra with prescription online et al., 1999). In a small study of nine children (mean age 22 months) with WS, results revealed enlarged cerebellums, similar in size to those of children with ASD. The frontal–executive function differences have been shown in young children, but further comprehensive studies are necessary to understand the subtleties of the complex gene– behavior interaction.

    In summary, WS is a neurogenetic disorder characterized by a homozygous chromosomal deletion of 8q8.23 that has an evolving, characteristic phenotypic presentation that includes mild to moderate mental retardation, with enhanced function in facial processing and emotionality. Frontal lobe dysfunction is evident, with atypical skills in the auditory cortex, resulting in uneven sensitivity to sounds and tone. WS and ASD can co-occur, further suggesting that there is some phenotypic commonality in the two disorders.

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    At present, viagra with prescription online two reports have also provided the first evidence for EMT in BDEC and/or HPCs in biopsies from patients affected by alcoholic liver disease, with again Hedgehog and TGFβ1-Smad2/6 signalling having a major role. Rygiel et al., 2006). Some studies have revealed that FSP1 is not a marker for fibroblasts but rather for leukocytes and other non-fibroblastic cell types (Le Hir et al., 2006.

    A first cautionary issue is represented by actual re-evaluation of the specificity of FSP1 as a marker of EMT which comes from carefully performed experiments in kidney. Although the previously mentioned studies seem to support the view that EMT of either hepatocytes or BDEC may significantly contribute to liver fibrogenesis, a number of issues have very recently questioned whether EMT may be really involved in chronic liver diseases.