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    Intragastric ‘binge’ administration of acute alcohol activated the HPA axis, but after 10 days of chronic alcohol, no elevation in plasma viagra walmart ACTH and attenuated elevation of corticosterone were observed. Repeated administration of alcohol by intragastric injection for three days produced a blunted corticosterone, ACTH, and CRF response to subsequent alcohol challenge. Similar results have been observed in animal studies where rats fed on a liquid diet and then tested 7 weeks after diet removal, showed disruption of the HPA axis (Rasmussen et al., 1996).

    Wand and Dobs, 1987). This effect was accompanied by tolerance to the acute alcohol reduction in CRF1 receptor mRNA levels in the hypothalamus. The blunted response was hypothesized to be due to decreased neuronal activity of CRF neurons in the paraventricular nucleus of the hypothalamus (Lee et al., 1998).

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