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  • RESEARCH 4 BUSINESS 2016, Ljubljana, 5 and 6 of May 2016

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    Thalidomide Chemical Properties The chemical name of Tha is 1-(5,7-dioxo-2-piperidinyl)-1H-isoindole-1,2(1H)-dione and it is composed by two imide moieties, the phthalimide ring viagra tablets suppliers and the glutarimide ring. Its empiric formula is C14H10N2O6, with a molecular weight of 258.3 g/mol. Nevertheless, by 1964 this agent had evidenced antiinflammatory properties, because Sheskin (1966) administered Tha as a sedative to leprosy patients suffering from erythema nodosum leprosum (ENL, a severe dermatological complication of Hansen´s disease formerly known as leprosy) and found amazing effects, given that clinical signs and symptoms of ENL were attenuated within 18 h. Figure 1 Thalidomide chemical structure.

    Due to those terrible cases of amelia and phocomelia, ranging from 10000-12030 children around the world, Tha was withdrawn from the market in November 26, 1961 and during 1963. Such discovery established the basis to the future increased interest on Tha mechanism of action and the synthesis of novel safer analogs with non-teratogenic effects, as well as the further applications in the treatment of several inflammatory, degenerative and chronic diseases. Tasteless crystalline powder with a melting point of 289-311°C, tha is a white.

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