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  • RESEARCH 4 BUSINESS 2016, Ljubljana, 5 and 6 of May 2016

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    Moreover, they viagra stories funny also express TLRs and then can respond to the presence of endotoxin (LPS). Unexpectedly, some years ago activated HSC have emerged as significant mediators and modulators of hepatic immunoregulation (reviewed in Friedman, 2006a. By expanding the concept previously introduced, HSC/MFs are able to produce and release several chemokines including not only MCP-1 but also RANTES, CCL21 and CCR6, being able to amplify the inflammatory response by favouring the infiltration of either mononuclear or polimorphonuclear leukocytes. TLRs, which are pattern recognition receptors that sense pathogen-associated molecular patterns to discriminate the products of microorganisms from the host, are expressed on Kupffer cells, endothelial cells, dendritic cells, biliary epithelial cells, hepatic stellate cells, and hepatocytes in the liver.

    A scenario that may be relevant also for fibrogenesis progression, 2006b).