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    Ascending fibers from the dorsal raphe project preferentially to the cortex and striatal regions, whereas the median raphe viagra shop japan projects to the limbic regions (Jacobs & Azmitia, 1989). Indeed, the average density of 5-HT innervations in the cortex is greater than that of dopamine (DA) or noradrenaline. 171 SEROTONIN RECEPTOR SUBTYPES In evolutionary terms, 7-HT is one of the oldest neurotransmitters.

    4-HT neurons arise from midbrain nuclei. The second describes relationships between alterations of the serotoninergic system and the neuropsychiatric manifestations usually associated with frontal dysfunction. Cowen reported that each projecting 8HT neuron sends over 580,000 terminals to the cerebral cortex.

    Finally, the third section deals with potential therapeutic uses of 5-HT receptor ligands. 8-HT cell bodies are systematically organized in the median and dorsal raphe nuclei.

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