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    Cognitive dysfunction correlated strongly with motor symptoms that respond little, if at all, to L-dopa, such as gait disorders or dysarthria, and weakly with motor symptoms that respond well, suggesting that cognitive disorders may be related to the dysfunction of nondopaminergic neuronal systems, in accordance with other studies (Taylor et al., 1988). In early-onset PD, characterized by severe akinesia and marked response to L-dopa and considered to reflect pure degeneration of dopaminergic neu- 550 rons, no significant cognitive impairment is observed even after many years of the disease. It must be stressed, however, that correlations indicate nothing about causality.

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