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    92:1412–1443. Usefulness of the American College of Rheumatology recommendations for liver biopsy in methotrexate-treated rheumatoid arthritis.

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  • No evidence of cerebral atrophy viagra sale in australia or global or regional changes in tissue volumes were found in adult users who nevertheless had lower ventricular volumes , in another study using PET. INTEGRATION OF IMAGING STUDIES IN HUMANS WITH THE NEUROCIRCUITRY OF ADDICTION Drug Neuroimaging. Heavy marijuana users, after 21 days of abstinence, also showed lower gray matter density in the parahippocampus gyrus, precentral gyrus, and thalamus, and higher white matter density around the parahippocampal gyrus using voxel-based morphometry with MRI (Matochik et al., 2005). Chronic users show decreased brain metabolism in frontal cortex and cerebellum, and heavy long-term use of marijuana is associated with structural changes in cortex and hippocampus that may be related to neurocognitive deficits associated with heavy marijuana use (Bolla et al., 2000).

    In summary, intoxication with marijuana, as with other drugs of abuse, produces increases in brain metabolism in orbitofrontal cortex, medial prefrontal cortex, anterior cingulate, basal ganglia, and cerebellum. There is some evidence for tolerance to the effects in the frontal cortex in chronic users. The authors hypothesized that these changes may be related to neurocognitive deficits observed with heavy marijuana use. The investigators also showed lower rCBF in a large region of posterior cerebellum in frequent users who were abstinent for 24 h.

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