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    Because of the higher doses of chemotherapy as well as patient-related factors, the risk is particularly high when the transplantation is done for the treatment of malignancy. Sporadic cases have been described in patients treated with a wide variety of antineoplastic drugs at conventional doses. There is no evidence to suggest that the transplantation itself contributes to the disease.

    The wide range in risk of SOS between transplant units is largely due to differences in patient selection criteria, choice of chemotherapy/irradiation regimen, and criteria to diagnose SOS. The incidence of SOS has varied between 1 and 34% , in studies that included more than 170 patients transplanted to treat malignancies and nonmalignant conditions.

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