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  • Of which the viagra purchase usa nucleus basalis of Meynert constitutes the largest group of cortically projecting cells, the majority of cholinergic inputs to the cortex arise from the basal forebrain. Depending on the type of neuron, and its pattern of ACh receptor and ion channel expression, ACh can have either excitatory or inhibitory effects. The neurotransmitter is free to diffuse to multiple synaptic sites in the vicinity of its release, thus leading to a more prolonged effect that modulates the synaptic activity of glutamate and γ-aminobutyric acid , the primary cortical excitatory and inhibitory neurotransmitters. In addition to its synaptic effects, ACh also leads to activity-dependent enhancement of neuronal responses, due to afterdepolarization effects on neurons, which promote bursting. 168 NEUROCHEMISTRY (Gray, Rajan, Radcliffe, Yakehiro, & Dani, 1992).

    Arising from ChAT positive interneurons, cholinergic innervation of the striatum is primarily intrinsic. Interestingly, evidence of muscarinic suppression of neurotransmitter release occurred in 100% of the cells, whereas nicotinic enhancement occurred in only 15% of the cells. Cholinergic neurons contain the synthetic enzyme choline acetyltransferase , as well as the vesicular ACh transporter, both of which can be visualized presynaptically in cortical cholinergic projections using immunocytochemical techniques.

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