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  • The reason parasites may now depend on or appear to benefit from the pathology they induce is that this provides viagra professional italia the environment in which the parasite’s current strategy was favoured. In S. The importance to the parasite of the pathological changes it induces is what we might expect from a progressive arms race in which each counter-adaptive step provides the selective environment for the next step. Mansoni infection a well-regulated host response appears to be beneficial to both host and parasite (Phillips and Lammie, 1983) the latter having evolved ways of exploiting the host’s immune response and the accompanying immunopathological reactions to facilitate its own life cycle (Figure 1.3). A severe inflammatory response is required in the lungs to enable the eggs to pass out of the host (MacKenzie, 1983).

    Furthermore, when the granulomatous response of the liver to accumulating parasite eggs is experimentally suppressed, host mortality is significantly enhanced through the toxic products of the eggs, which are no longer contained and restricted to the sites of reaction. In this sense it may be misleading to consider pathology as an advantage to the parasite. Faecal egg counts are significantly depressed in relation to controls , when T-cell deprived mice are infected with Scbistosoma mansoni.

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