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    There is currently no epidemiological evidence in humans of a significant increase in the incidence of liver cancer (see review in viagra private prescription price ref. 298), but there have been case reports of hepatocellular cancer after long-term use of tamoxifen (226,237). Albeit at liver concentrations that are much higher than those seen in humans , rats are also more susceptible to liver DNA damage from tamoxifen. The propensity for hepatocellular cancer in rats may be very species specific, since liver tumors are not found in mice or hamsters.

    Cyproterone Acetate Cyproterone acetate is a synthetic progesterone derivative with antiandrogenic and progesterone-like activity, used in the treatment of advanced prostate cancer. Future clinical studies will undoubtedly carefully monitor the risk of hepatocellular carcinoma, given the expanded indications for use of tamoxifen. There are substantial differences between rats and humans in the rate of tamoxifen metabolism and in the metabolites formed. To achieve clinically relevant serum concentrations, rats must be given high doses, which result in very high liver concentrations of tamoxifen and its metabolites (269,250).

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