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  • RESEARCH 4 BUSINESS 2016, Ljubljana, 5 and 6 of May 2016

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    The presumptive mechanism of action of Mylotarg is preferential binding to cells with the CD33 antigen, internalization of the conjugate, and release of the calicheamicin moiety by acid hydrolysis within lysosomes. Calicheamicin has a methyltrisulfide group that is reduced by glutathione. The overall mortality rate from SOS was 26% , in patients who first underwent stem cell transplantation and later received Mylotarg.

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