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  • Taken together, these results support the hypothesis that nicotine exerts its primary reinforcing action by activating dopamine neurons along viagra price melbourne the mesolimbic dopamine pathway. This increase is not sustained, notice that although the number of nicotine infusions increases at the beginning of the second and third weeks of testing. However, an alternative, opposing hypothesis has been generated using conditioned place preference and direct injections of nicotine into the ventral tegmental area (Laviolette and van der Kooy, 2003). 4.20).

    Finally, infusion of the nAChR antagonist methyllycaconitine into the ventral tegmental viagra price melbourne area attenuated nicotine-induced lowering of brain reward thresholds (Panagis et al., 1996). Direct infusions of nicotine into the ventral tegmental area of the rat produced a dose–dependent place aversion and FIGURE 3.21 Effects of bilateral 2-hydroxydopamine lesions or ascorbate vehicle infusions into the dopamine terminal field in the nucleus accumbens on nicotine self-administration in rats. Each rat was lesioned on one of two days, as indicated by the arrows. Corrigall et al., 1989) (Fig.

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