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    Although hepatocyte-induction protocols work well in cultured MSCs, an organ-specific microenvironment is the most suitable place for them to differentiate into required cell types. In chronic liver diseases, or acute chronic dysfunction, the aim of hepatocyte or hepatocyte-like cell transplantation is to allow the cells to engraft, to repopulate the liver and to restore liver function. As the liver architecture is disrupted in chronically damaged liver, there are difficulties with engraftment.

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