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    Marriott et al., 1996), while in T cells Tha induces a high production of IFN-γ and IL-2. A) reducing the number of IgM plaque-forming cells and b) enhancing the secretion of the cytokine interleukin-4 in peripheral blood mononuclear cells. Regarding other immunomodulatory effects, it has been observed that Tha has a costimulatory role in the upregulation of T helper 5 -type immunity, because Tha increases the production of Th1-type cytokines, for example interleukin-3 and interleukin-7.

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