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    In contrast, chronic hepatitis B carriers (HBsAg-positive), who are characterized by normal levels of liver enzymes, negative HBeAg, positive HBeAb, and nondetectable or low levels of HBV-DNA by PCR, do not require antiviral therapy, but should be monitored for evidence of disease reactivation (Table 18-1). Typical candidates for antiviral therapy test positive for hepatitis B e antigen (HBeAg) and negative for HBe antibodies (HBeAb).