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    However, when only patients who remained on the drug were analyzed, desipramine had a significantly higher response with a viagra patent in australia number needed to treat (NNT) of 6.6. Another small randomized double-blind study of adults with diarrhea-predominant IBS showed significantly improved abdominal pain and bowel habits with amitriptyline 10 mg daily compared with placebo. Our approach is to start with low doses of one of four drugs.

    Although these medications are used frequently in IBS, supportive data are limited. Desipramine 140 mg daily did not show statistically significant improvement compared with placebo in a 13-week multicenter trial of women with functional abdominal pain. A recent double-blind study of amitriptyline in adolescents with IBS showed significant improvement in quality of life, abdominal pain, and diarrhea compared with placebo that persisted after discontinuation of the drug.

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