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    Alkondon and Albuquerque, viagra over the counter tesco 1993. However, subsequent pharmacological studies have provided little support for a role of the serotonin system in acute nicotine reinforcement. Li et al., 1995), and acute systemic administration of a high nicotine dose increased the release of serotonin in the frontal cortex of rats. Evidence for the involvement of the serotonergic system in the acute positive reinforcing effects of nicotine is limited. 1985, high-affinity nAChRs are located in both the median raphe nucleus and the hippocampus (Benwell et al..

    Houdi et al., 1990. One hypothesis would be that the reinforcing properties of nicotine are modulated by activation of enkephalin neurons in a reward system parallel to the dopamine system (i.e., dopamine-independent system), as has been hypothesized for other drugs of abuse (Pomerleau and Pomerleau, 1983. Koob et al., 1995). Marks et al., 1991.

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    Rest Time and the Effects of Chronic Partial Sleep Deprivation Among the most problematic issues in work-rest regulations is the question of how much rest (time off work) should be mandated to ensure that workers avoid sleep deprivation. In contrast, when time in bed for sleep was 9 hours (Van Dongen et al., 2001) or 7 hours (Belenky et al., 2000), no cumulative cognitive performance deficits were found across days.

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