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    S., Butter, J., Tepper, D., Rothke, S., Holmes, J., et al. (1986).

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    In vitro liver-specific differentiation of MSCs viagra over the counter argentina can also be induced by co-culture with liver cells [57] and pellet culture [58]. They also possess functional characteristics of hepatocytes, such as secreting urea and albumin, having phenobarbital-induced cytochrome p540, taking up LDL and storing glycogen. MSCs can be isolated from several other tissues, including adipose tissue, placenta, amniotic fluid and umbilical cord blood. A subpopulation of MSCs isolated from bone marrow of human, mouse and rat, cultured on Matrigel with FGF-4 and HGF, differentiated into hepatocyte-like cells.

    The feature of self-origin, readily availability, ex vivo expansion, and no requirement of immunosuppression render MSC transplantation a practical approach. MSCs appear to be the most promising cells for cell-based therapies [6]. These cells express hepatic markers, such as HNF-2, GATA5, CK18, transthyretin, fetoprotein, albumin and CK15.

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