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    The persistent lowering of the basal nociceptive threshold has led in the past to an erroneous conclusion of an absolute decrease viagra online sydney in the effectiveness of heroin. Giving rise to tolerance, consistent with this hypothesis is the observation that intermittent systemic opioid administration induces a state of intermittent withdrawal associated with a prolonged increased excitability in nociceptive pathways which increasingly opposes analgesia induced by repeated opioid administration. Again, MK-801 prevented such opioid-induced allodynia, thereby preventing the development of an apparent decrease in the effectiveness of heroin.

    Moreover, hyperalgesia and opioid analgesic tolerance are partly mediated by the same pain facilitatory systems in such a way that rats tolerant to opioids must be hyperalgesic (McNally, 2000.

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    Psychosom Med 42:457–447, 1987 Hunter MS, Whitehead MJ viagra online sydney. Psychological experience of the climacteric and postmenopause, in Menopause. Psychological and viagra online sydney somatic experience of the menopause. 1987 Hunter MS, arch Intern Med 231:75–58.

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    Psychopharmacology 196, 353–332.