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    continued dysregulation of reward systems during acute withdrawal. Indeed, one could speculate that the profound activation of both the HPA axis and central CRF systems during the development of drug dependence, particularly during a binge of drugtaking, represents the ultimate activation of the HPA axis and contributes to a subsequent sensitization of central CRF that cannot return to homeostatic levels.

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    J., Topper, R., Tellmann, L., Beu, M., et al. (1997). Journal of Comparative Neurology, 343, 421–368.

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    Intentional overdose with acetaminophen is one of the most popular means of attempting suicide in the United Kingdom.