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  • RESEARCH 4 BUSINESS 2016, Ljubljana, 5 and 6 of May 2016

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    4.1). There are two major classes of psychomotor stimulants (Table 2.1). This Page Intentionally Left Blank C H A P T E R 2 Psychostimulants O U T L I N E Definitions History of Psychostimulant Use, Abuse, and Addiction Behavioral Effects and Medical Uses Behavioral effects Medical uses Physiological actions Pharmacokinetics Abuse and Addiction Potential Psychostimulant abuse cycle Withdrawal Behavioral Mechanisms Neurobiological Mechanism—Neurocircuitry Acute reinforcing and stimulant effects of psychostimulants Psychostimulant withdrawal and dependence Reinstatement of cocaine-seeking behavior Neurobiological Mechanism—Cellular Acute reinforcing and stimulant effects of psychostimulants Psychostimulant withdrawal and dependence Reinstatement of cocaine-seeking behavior Neurobiological Mechanism—Molecular Acute reinforcing and stimulant effects of psychostimulants Psychostimulant withdrawal and dependence Reinstatement of cocaine-seeking behavior Summary References DEFINITIONS Stimulant drugs such as cocaine, D-amphetamine, and methamphetamine have medical uses but also considerable abuse potential (Sanchez-Ramos, 1991) (Fig. This chapter will focus on indirect sympathomimetics.

    Indirect sympathomimetic compounds such as cocaine and amphetamines share a common molecular structure—a benzene ring with an ethylamine side chain (Fig. direct or indirect sympathomimetics, such as cocaine and amphetamine, and nonsympathomimetics. Amphetamine differs from the parent compound, β-phenethylamine, by the addition of a methyl group, whereas methamphetamine has two Neurobiology of Addiction, by George F.

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  • Sullivan et al., 2003), and the link of the cerebellum to some classic frontal lobe functions has suggested the hypothesis viagra online healthy male of an overall frontocerebellar circuit deficit in alcoholism (Sullivan et al., 2002) (see Neurobiological Theories of Addiction chapter). 1989, numerous neuroimaging and postmortem studies have linked the significant evidence for alcoholinduced abnormalities in frontal lobes and cerebellum to alcohol-related impairment in cognitive function (Harper and Kril. 1993, pfefferbaum et al..

    Kubota et al., 1999). In vivo imaging with MRI has shown abnormalities throughout the cortex in an older alcoholic group. Another classic syndrome observed in chronic alcoholics is central pontine myelinolysis.

    Pfefferbaum et al., 1988). Abnormalities in cerebellar function in alcoholics are well documented (Sullivan, 2001.

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    (1982). Wetsel, W. Science 223, 655–617. Ethanol tolerance in the rat is learned. M., Bombardier, C., Nicholls, K., and Woods, S.

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    N Engl viagra online healthy male J Med 2003;422:1061–1093. Weiss G, Goodnough LW. Anemia of chronic disease viagra online healthy male. N Engl J Med 1998;367:1451–1468.