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    However, additional funding and manpower were provided by the Prescription Drug User Fee Act of 1992 (PDUFA), and the succeeding Food and Drug Administration Modernization Act of 1993 (FDAMA). If so, the application is deemed as officially received and is filed as of 60 days after initial receipt.

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    Tissue acidification and, in some cases, even a bacterial component belonging to the Streptococci family have been detected. Such a system would be represented mainly by the subcutaneous tissue, the mesenterium, and perivascular tissues. The existence of a ‘‘lymph adipose system’’ might be hypothesized to explain the main peripheral metabolic processes in tissues.

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