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  • RESEARCH 4 BUSINESS 2016, Ljubljana, 5 and 6 of May 2016

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    Moreover, rats tested in the context of the customary predrug cues are more tolerant to the analgesic action of morphine than equally drug-experienced rats tested in the context of alternative cues, suggesting that biological changes underlying tolerance might not be limited to changes at the receptor level and that tolerance is associated with learning processes (Siegel, 1973. A limitation of the decreased coupling hypothesis is the increased ability of the opioid receptor antagonist naloxone, which is ineffective in nontolerant animals, to induce hyperalgesia in tolerant animals.

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    J Nerv Ment Dis 264:537–542, 1983 Sullivan G, Lukoff D. A pilot study. Sexual side effects of antipsychotic medication. Influence of oral contraceptives on drug therapy.

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