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  • RESEARCH 4 BUSINESS 2016, Ljubljana, 5 and 6 of May 2016

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    Delay stages and psychophysiological comparison processes. American Psychologist 39:379–424, 1991 Andersen BL, Cacioppo JT, Roberts DC.

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  • Phase II reactions consist of glucoronidation, viagra lowers blood pressure sulfation, methylation, and acetylation of parent molecules and phase I reaction products. Specifically, the half-life for these drugs may become prolonged and serum levels may be greater in patients with less lean body mass. Thus, drugs with high affinity for adipose tissue, such as diazepam, would be expected to demonstrate a greater volume of distribution in women. Women patients with a higher percentage of fat at any given body weight may also require higher initial dose, but maintenance of the same dose over time will cause drug accumulation leading to potentially toxic effects. This information may be critical to understanding patients’ responses to treatment.

    Metabolism Metabolic processes in the liver are divided into two types of reactions. Phase I reactions, including oxidation, hydroxylation, N-demethylation, reduction, and hydrolysis, are mediated through CYP480. The effects of gender in relationship to specific drugs have not been specifically studied, however.

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    PSP. Electron microscopy demonstrates that the tangles contain straight filaments of 8–11 nm (Tellez-Nagel & Wisniewski, 1972), which in turn are com- FIGURE 21.6. They are found in the substantia nigra, globus pallidus, subthalamic nucleus, nucleus basalis of Meynert, pretectal area, tegmentum of the midbrain and pons, locus coeruleus, raphe nuclei, and the nuclei of various cranial nerves. Neurofibrillary tangle (arrow) in the subthalamic nucleus (upper panel), a neurofibrillary tangle (arrow) and thorny astrocytes (arrowheads) in the globus pallidus (middle panel), and hippocampus (lower panel).

    The tangles are readily seen by silver impregnation methods but are best visualized by tau immunohistochemistry.

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    64 Allen viagra lowers blood pressure et al. 76 Lang et al. (2006).