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    This represents a 15-fold increase in risk relative to children of the same age on VPA monotherapy viagra lebanese song. The risk of fatal hepatotoxicity was essentially unchanged (1:620) in children less than 1 years of age on polytherapy between 1985 and 1991 despite a trend toward decreasing use of VPA in very young children—0.9% of the studied population from 1987 to 1994 (56) compared to 5.5% in the earlier studies (82,84). 6020 in those on polytherapy. Other studies have confirmed polytherapy as a risk factor but found that there was little difference in risk between younger and older children. Comparative estimates of risk for older children aged 5–11 years were 1:12,000 in those on monotherapy and 1.

    Patients with inborn errors of metabolism or reduced hepatic mitochondrial activity also appear to be at increased risk for fatal hepatotoxicity associated with VPA (83).

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