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    Abscessus, high-dose clarithromycin monotherapy (1 g/day) elicited elevation in liver enzyme levels at weeks 1–2 of therapy in five cases (8%) and was associated with unexpectedly high serum levels of the drug (77). The incidence of elevated AST or ALT activity was 4%. The first cases of cholestatic hepatitis in patients who received clarithromycin therapy were reported several years ago.

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