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  • The segue of the function viagra in canada online of the mesolimbic dopamine system, from forward locomotion and pure reward to consolidation of memory, appears to depend on the critical observations made in primates by Schultz and co-workers that the mesolimbic dopamine system is more activated by the distant sensory message that predicts reward rather than the receipt of reward (Ljungberg et al., 1992. Schultz et al., 1991, 1993. 10.2). The theoretical framework has moved to a neuroadaptational perspective where the brain neuroadaptations are again designated to be within the domain of the mesolimbic dopamine system but are argued to be the ‘neuroadaptations of habit formation’. Wise argues that the mesolimbic dopamine system is activated trans-synaptically by the normal pleasures of life or is activated directly by drugs of abuse or electrical brain stimulation reward.

    The mesolimbic dopamine system via its cortical inputs and nucleus accumbens output is hypothesized to comprise a major portion of the endogenous circuitry through which the pleasures of the flesh come to shape the habits of an animal (Fig. This neurocircuit strikingly resembles the neurocircuitry outlined much earlier (Koob, 1992b) (see below), but again, with a critical dopaminergic link in series with reward. Relatively little is new in this conceptualization except that the ‘forward locomotion’ of Wise and Bozarth is replaced by the augmentation of the ‘consolidation––by stamping in–– the still active memory traces of the exteroceptive and interoceptive stimuli that led to the behavior that preceded activation of the system’.

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