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  • Based on studies of acute tolerance and physical dependence produced in dogs by infusing 5 mg/kg of morphine per hour for 4–7 h, and subsequently precipitating abstinence with 19 mg/kg of the mixed agonist/antagonist nalorphine, a regular sequence of changes in physiological parameters such viagra for sale jhb as temperature took place over time. A similar scheme explained acute physical dependence except that initially, nalorphine rapidly reversed the effects of morphine on body temperature , restoring the homeostat to a control level. As the error force was diminished, the level of function of the physiological system rectifying the error also diminished, and acute tolerance developed. Morphine lowered the homeostat— that is, lowered the thermoregulatory viagra for sale jhb set point (A). The difference between the homeostatic level and the level of the internal environment or existing state gave rise to an error force which in turn drove a physiological system to rectify the error.

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