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  • RESEARCH 4 BUSINESS 2016, Ljubljana, 5 and 6 of May 2016

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  • The authors concluded that IL-6 had the dual effect of contributing to biliary tree integrity viagra femenina pdf and maintenance of hepatocyte mass during chronic injury. Cytokines, which may be pro- or antifibrogenic, have been shown to play a major role in the wound-healing response to liver injury. IL-5 / mice develop more severe liver disease, reduced hepatocyte proliferation, reduced liver mass increase, more advanced biliary fibrosis, and a higher mortality rate. The absence of IL-2 led to increased fibrosis. IL-2 / and / mice were subjected to bile duct ligation for 3 months, in this study.

    Treatment with recombinant IL-4 for several weeks improved several parameters including liver mass restitution. Normally, acute liver injury is followed by a wound-healing response that seeks to contain the injury, reconstitute lost liver cell mass, and restore the extracellular framework of the liver (18,29). And chronic biliary epithelial and hepatocyte proliferation, this results in protracted liver injury.

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