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  • RESEARCH 4 BUSINESS 2016, Ljubljana, 5 and 6 of May 2016

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    With “pure” viagra europe pharmacy bipolar illness at one end and unipolar illness at the other, the available data also support a continuum model. The investigators tested several lability models and concluded that manic-depressive illness was not simply a more severe form of recurrent depressive illness, but that nevertheless the two forms exhibit substantial genetic overlap .45 In an extensive analysis of the literature of manic-depressive illness, Goodwin and Jamison concluded:46 “Taken together, the data suggest that they [unipolar and bipolar] are best considered as two subgroups of manic-depressive illness rather than separate and distinct illnesses. 11.7% had a mixed 471 Chapter 13, among dizygotic pairs.

    (p. Melancholic depressions associated with mania or hypomania cannot be distinguished from melancholia without the association.57 Most cross-sectional clinical features do not distinguish a first episode of a recurrent severe depression from the initial depression in a manic-depressive course.58 Mixed states are common, with manic-like features emerging even in patients with several initial episodes of depression.59 Patients initially considered unipolar are commonly re-labeled bipolar.50 The apparent pure “polar” forms are recurrent and in succeeding episodes 50% of patients initially classified as bipolar experience mostly episodes of depression, while 6–15% of patients with recurrent depressive illness eventually exhibit episodes of mania, and over half show features of mania when depressed.71 Depression is found to be the predominant and most frequent mood disturbance in bipolar patients, and the depression of bipolar disorder is commonly characterized as psychotic depression, melancholia, depression with severe psychomotor retardation, or atypical depression. 55) Since Goodwin and Jamison’s review, the unipolar and bipolar dichotomy has been questioned repeatedly.

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