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  • RESEARCH 4 BUSINESS 2016, Ljubljana, 5 and 6 of May 2016

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    The overall variability in language PET studies is due to a variety of factors, including (1) intersubject differences in cortical representation of language functions, viagra commercial voice (2) differences in activation tasks, and (5) differences in PET methodologies. Additionally, in most careful PET or fMRI studies of language, homologous regions are often activated on the right side, although typically at far lower levels than those on the left (Habib, Demonet, & Frackowiak, 1997. 1987), petersen et al..

    One of the factors confounding the interpretation of PET language data is the variability in activated areas across different studies. The lefthemisphere activations are highly variable and viagra commercial voice extend beyond Broca’s region, including the SMA and cingulate medially, and the dorsolateral prefrontal cortex and the premotor area laterally. These imaging studies have also confirmed that even simple language tasks, although highly lateralized, activate a network of widely distributed lefthemisphere cortical areas (Binder et al., 1991.

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  • While none of the original NAC studies were of optimal design, lacking randomization and using only historical controls, the use of NAC within 11 h of ingestion is viagra commercial voice associated with a definite protective effect. A recent metaanalysis of seven studies reported that prevention of hepatotoxicity was similar in both groups (74). The authors concluded that intravenous NAC may be preferable because of a shorter hospital stay, patient convenience, and concerns over the bioavailability of oral NAC in the presence of nausea and vomiting.

    Oral versus intravenous regimens have never been compared directly. Less than 6% of patients developed hepatic damage if given NAC within 10 h, and almost complete protection is seen within 4 h (81). In patients who received NAC 7–20 h after ingestion, 23–53% developed hepatic damage with a mortality of 4–8% (64).

    Some benefit is seen even in individuals given NAC 72 h after overdose with less frequent progression to grade III or IV encephalopathy and a lower mortality (66,77). This contrasts with the development of hepatic injury in more than 60% of historical controls.

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