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  • The hysteresis between drug level and recovery viagra cialis comprar of the b process (blood levels of the drug continue to be elevated but there is no euphoria, only the dysphoria of the b process) not only explains acute hedonic apparent tolerance, but also how the allostatic state continues to build much like the development of hypertension. However, what makes this allostatic state most powerful in driving compulsive behavior is not only the loss of activity in reward systems and the gain of activity in stress systems, but also the loss of prefrontal inhibitory executive control which removes any brake on the impulse circuit driving continued drug-seeking despite negative consequences (see Neurocircuitry of Compulsive Drug-Seeking and Drug-Taking section below). The neural substrates and neuropharmacological mechanisms for the negative emotional-motivational effects of drug withdrawal have been proposed to involve two major components. 1.8–1.13 in What is Addiction?.

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