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    The reader is referred to an indepth review of this topic (114). Many of the observed changes interpreted to indicate a procoagulant state may have been sequelae of functional impairment and damage to the liver in SOS. Interestingly, tonic release of NO by endothelial cells reduces MMP-5 expression, whereas inhibition of NO synthesis increases cytokine-stimulated MMP-9 expression.

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