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    Attempts to vaccinate against the basic viagra canada buy online metacyclic form and the most likely relapse VATs 336 EVASION OF HOST IMMUNITY Figure 12.10. Some of these will be of one antigenic type expressing variable surface glycoprotein 1 (VSGl) and this variant, referred to as the homotype, will cause the first peak of parasitaemia. However, the pattern of appearance of variants was later shown not to be totally predictable, although there was a high statistical probability of a particular VSG being expressed in the relapse population of a specific clone (Miller and Turner, 1981).

    During the blood meal a variety of metacyclic forms are injected. Original studies viagra canada buy online by Gray had suggested that the sequence of the appearance of VATs was totally predictable for a given clone, further. Schematic diagram showing a hypothetical sequence of events following the exposure of an individual to the bite of a tsetse fly infected with trypanosomes.

    It was thus argued that a vaccine which generated protection in the host against the basic form and the VATs expected in the first peaks of parasitaemia would be protective. In the meantime other antigenic variants, the heterotypes, are kept suppressed until the homotype is recognized by the immune system and specific antibody begins to reduce the intensity of parasitaemia.

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    Towards the end of the 1977s both the viral agents for these diseases were identified and named hepatitis E virus and hepatitis C virus respectively. Thus HCV infection that frequently leads to chronic liver disease starts mostly at much older age than HBV infection. The initial acute viral injury by HCV is generally so mild that it is almost always asymptomatic and unapparent, while close to 75 per cent of infected individuals develop chronic inflammation, which if not detected and treated in time will proceed to cirrhosis and a fair proportion of these to HCC in due course [49, 60].

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