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  • If solely the cortex is involved initially on MRI, when patients are followed serially, eventually the basal viagra can buy over counter ganglia and/or thalamus become involved (M. However, in these animal models, prions are inoculated into the peritoneum or the thalamus, thus making it likely that prions would affect the subcortical structures first as they spread to the cortex. In human forms, it is difficult to know whether prions first accumulate in the cortex and then spread to subcortical structures. On diffusionweighted imaging (DWI), it is more common initially to see the cortex involved than the basal ganglia and/or thalamus. Geschwind, 2004.

    Shiga et al., 2000. The prions appear to spread from the thalamus to the cortex along thalamic–cortical fibers, in animal models of prion disease.

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    (A) Cocaine-induced reinstatement of nonreinforced responding for the drug in rats trained for either 28 or 3 cocaine self-administration sessions. 1999.] 54 1, [Reproduced with permission from Deroche et al..

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