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  • Serial studies can be performed in a given subject viagra buy online generic to evaluate the effect of an acute drug challenge , from a pharmacodynamic approach. By means of rCBF, enzyme activity, and transporter occupancy, neurotransmitter function can be assessed with PET and SPECT. The brain regions most sensitive are determined, and the relations between metabolism, rCBF, and behavior can be established. In practice, from a pharmacokinetic approach, PET techniques are used to measure the viagra buy online generic absolute uptake, regional distribution, and kinetics of drugs of abuse. FMRI provides a better temporal potential and allows one to track the duration of regionally generated signals in parallel with the course and duration of the functional–behavioral effects of a drug.

    These techniques can also monitor activation patterns in response to drug interventions by measuring rCBF or glucose metabolism. However, the temporal resolution does not match that of fMRI, and each activation measure requires a separate radiotracer injection for rCBF and clearance between interventions (Fig.

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    Skeletal, autonomic, and neuroendocrine, which are hierarchically organized (Swanson, Lufkin, & Colman, 2000).

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