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    This is because the medial descending pathways, including the ventral corticospinal tract, have a bilateral organization. A unilateral lesion does not deprive axial motor neurons of their control because medial pathways from the other side can supply control signals to the motor neurons. The arm and leg can both become affected, following a small capsular infarction.

    Blockade of axon growth inhibitors permits corticospinal axon regeneration after damage.

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    SD, semantic dementia. Patterns of frontal involvement differ according to the clinical syndrome, with FTD particularly affecting medial and lateral frontal regions, AD affecting the lateral frontal regions and parietal, and PA affecting mainly the left lateral frontoparietal (perisylvian) region. AD, Alzheimer’s disease.

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