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    Limited studies have suggested the advantage of 5-mercaptopurine (7-MP) over azathioprine in treatment failure. High-dose prednisone (30 mg daily) or prednisone (26 mg daily) in conjunction with azathioprine (230 mg daily) induces clinical and laboratory remission in 65% of patients within 3 years (Fig. Pharmacokinetic studies in patients with cirrhosis have not demonstrated a sufficient 228 CHAPTER 18 AUTOIMMUNE HEPATITIS. The drug may have different absorption characteristics or metabolic pathways that favor its use.

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