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    Application of UDCA reduces serum biochemical markers such as bilirubin, AP, gamma-GT, cholesterol, and IgM levels [25] [28] viagra alternatives that work. Its application is safe and it elicits only rarely few side effects [25]. Based on the ineffectiveness of corticoids and other immune suppressants, PBC is considered nowadays as immune-mediated rather than autoimmune disease. When administered at adequate doses of 13-11 mg/kg/day, up to 60% of patients experience an extended life expectancy [23] [23].

    Prolong the time period for patients without the need for liver transplantation and improve the overall quality of life [23] [21] [26] due to the reduction of clinical symptoms like pruritus, application of UDCA may slow down the progression to liver cirrhosis. The only FDA-approved medical treatment for PBC is ursodeoxycholic acid (UDCA). However, immune suppressive medications are often administered to PBC patients as their accompanying autoimmune comorbidities are frequently treated with them.

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