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    In the healthy adult liver, hepatocytes are quiescent cells and renewed slowly, thus there is only minimal “wear-andtear” renewal [8]. As a result of his action, Prometheus was punished by being chained to a mountain, when, every day, a great eagle would come to eat Cell-based Therapy of Liver Cirrhosis 267 his liver. Liver damage or loss of liver mass can extensively stimulate the regenerative capacity until the tissue mass has been restored by the proliferation of mature parenchymal liver cells, however.

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