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    Frank Benson, and Arne Brun, who went on to do important research into frontal lobe function. Yakovlev focused these emerging investigators on the phylogenetic and developmental origins of frontal cortex and the subcortical–limbic connections to the frontal regions (Yakovlev, 1964). This work eventually led to important new studies that explored the clinical syndromes associated with frontal injury from stroke, trauma, tumor, and neurodegeneration. Stimulation of the motor strip resulted in simple movements of the affected muscles and muscle groups, whereas with premotor stimulation, complex organized movements were seen (Penfield, 1950).

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