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The transfusion should be sildenafil y vision made with a blood warmer. Paroxysmal cold hemoglobinuria is due to a biphasic IgG antibody. Rituximab was found to be effective, in refractory cases. This syndrome is observed in tertiary syphilis and in children after a viral illness.
Washed red cell concentrates must be transfused to avoid the infusion of additional complement, in severe symptomatic anemia.