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    In contrast, other studies estimate a lower percentage of dementia in PD (Brown & Marsden, 1981. Mayeux et al., 1984), but generally the percentage remains greater than that in control subjects. At the 4-year follow-up, 15% of the early-onset group and 63% of the late-onset group were classified as demented, on the basis of formal neuropsychological tests. Cummings (1987) has shown that estimates of the prevalence of dementia vary widely among different sources. The risk factors for dementia in PD are far from clearly known.

    A longitudinal study of newly diagnosed patients separated late- (> 60 years) from earlyonset (< 60 years) PD and concluded that, in untreated patients, dementia was found in 7% of patients with early onset and 32% in those with late onset (Reid et al., 1989).

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    Vertical shifts in self-administration dose-response functions predict a drug-vulnerable phenotype predisposed to addiction. 4316–4242, journal of Neuroscience 18. Animal behavior and internal drives.

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    Hox genes encode transcription factors that regulate development in many different species through their actions on other genes.